Union of Basic and Clinical Pharmacology (IUPHAR) 2014 ... ??International Union of Basic and Clinical Pharmacology (IUPHAR) 2014‐2018 Executive Committee Teleconference May 9, 2017 Minutes

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InternationalUnionofBasicandClinicalPharmacology(IUPHAR)20142018ExecutiveCommitteeTeleconferenceMay9,2017Minutes 1 ParticipantsDarrellAbernethy,USA,ChairofClinicalPharmacologyDivisionLeighAnnArbuckle,USA,TreasurersAssistantJamesBarrett,USA,CouncilorPatrickduSouich,Canada,PastPresidentS.J.Enna,USA,PresidentGraemeHenderson,UnitedKingdom,FirstVicePresidentMasamitsuIino,Japan,SecondVicePresidentLynnLeCount,USA,AdministrativeSupportMariaIsabelLucena,Spain,Treasurer,ClinicalDivisionFrancescaLeviSchaffer,Israel,CouncilorEevaMoilanen,Finland,CouncilorBhagirathPatel,India,CouncilorMichaelSpedding,France,SecretaryGeneralPetraThrmann,Germany,TreasurerDavidWebb,UnitedKingdom,ViceChair,ClinicalDivisionYongXiangZhang,PRChina,CouncilorUnavailableDavidLeCouteur,Australia,SecretaryGeneral,ClinicalDivisionDiscussionTopicsWelcomeSecretaryGeneralMichaelSpeddingthankedtheparticipantsfortheirtimeinjoiningthisdiscussion.Hehighlightedafewrecentinitiatives,includingtheClinicalPharmacologyMentoringCentersimplementedbytheClinicalPharmacologyDivision;anInternationalConferenceonMechanismsofActioninNutraceuticalsinSeptemberbeingcoorganizedbythePharmacologyofNaturalProductionsSection;andthealphareleaseoftheGuideToImmunopharmacology.orgbytheDatabaseTeaminconjunctionwiththeImmuPhar(Immunopharmacology)Section,aswellaseffortsbyImmuPhartoforgeacollaborationwiththeInternationalUnionofImmunologicalSciences.TreasurersReportReview2016financialsTreasurerPetraThrmannreportedthattheeconomyisdoingsomewhatbetter,whichhasbenefittedIUPHAR.TheTreasurersAssistant,LeighAnnArbuckle,summarizedthe2016yearendfinancialstatement.ShereportedtwodonationswerereceivedfromServierduring2016,ofwhichthefirstfulfilledthe2015pledgeandthesecondfulfilledthe2016pledge.Ms.ArbuckleacknowledgedgenerosityofServierhadbeenpivotalinhelpingIUPHARmeetitsexpensesfortheyear.During2016,~US$115kwasreceivedinduesfromIUPHARmembersocieties.Alongwithsomemiscellaneousrevenue,thetotal2016incomeamountedto~US$198k.Asthe2016expensestotaled~US$154k,therewasagrosssurplusof~US$44k.Unfortunately,thesluggishglobaleconomyresultedinalossofUS$11kontheinvestmentaccounts,resultinginanetsurplusfor2016of~US$33k.TherewerenoquestionsfromtheExecutiveCommitteemembersregardingthe2016yearendfinancialstatement.Review2017budgetMs.Arbucklereportedthat,effectiveMarch31st,~US$60khadbeenreceivedoftheanticipated~US$119kinmembersocietyduesfor2017.ShehasbudgetedUS$17.5kforthe2017ExecutiveCommitteemeeting.TakingintoaccounttheexistingencumbrancesonbehalfoftheIUPHARInternationalUnionofBasicandClinicalPharmacology(IUPHAR)20142018ExecutiveCommitteeTeleconferenceMay9,2017Minutes 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DivisionandSections/Subcommitteesandtheexpectedoperationalexpenses,alongwithananticipateddonationfromServier,Ms.Arbuckleprojectsalossof~US$12.8kattheconclusionof2017,however,thisamountdoesnotreflectgainsorlossesgeneratedbytheinvestmentaccounts.AsofMarch31st,therewas~US$11.7kintheIUPHARcheckingaccounts.PresidentSamEnnaalertedthegroupthatduringtheIUPHARNomenclatureCommittee(NCIUPHAR)meetingheldthepriorweek,heandDr.Speddinghadreviewedthestatusofthebudgetwithitsmanagementteam.Dr.SpeddingnotedthatthefundingfromtheBritishPharmacologicalSocietyandWellcomeTrusthadbeeninstrumentalinallowingtheexpansionoftheGuidetoPharmacologywebsitefeaturesanddatabasecontentsandnowtheGuidetoImmunopharmacology.Atthistime,theyarepreparingagrantapplicationforanadditionalexpansionofthedatabaseonantibioticsaspartoftherecentemphasisbytheWorldHealthOrganization.CouncilorFrancescaLeviSchafferencouragedtheexplorationofapossiblegrantonthesametopicfromtheUnitedNationsEducational,ScientificandCulturalOrganization.StatusofactionitemsfromMelbourneminutesDr.ThrmannwillcontactUBSinlateJanuary,2017tomaketheinvestmentundertheconditionsapprovedbytheExecutiveCommittee.Thisactionhasbeencompleted.Dr.BarrettwillcontactafewpublisherstoexplorepublishingopportunitiesforIUPHAR.Dr.BarretthasinitiateddialogswithSpringerandElseviersowillreportfurtheronhisfindingsduringtheExecutiveCommitteemeetinginRimini,ItalyinOctober,2017.Ms.LeCountwillincludeonthe2018GeneralAssemblyagendathetopicofappointingDufourTreuhandastheIUPHARexternalauditor.ThetopicshavebeenplacedonfilefortheJuly4,2018IUPHARGeneralAssembly.Dr.SpeddingshouldcontactDr.LarsGustafsson,thechairoftheClinicalPharmacologyinDevelopingCountriesSubcommitteeoftheIUPHARClinicalDivision,andDrs.KalleHoppu,MarjaLiisaDahlandSimonMaxwelloftheIUPHARLiaisonCommitteetotheWHOtoestablishformalcontactswithinWHO.Thisactionitemisongoing.Dr.SpeddingwillprovideanupdateduringtheExecutiveCommitteemeetinginRimini.Dr.SpeddingwillencourageDr.OhlsteintoseekopportunitieswherepublisherswillpayIUPHARfortherightstopublisharticlesfromaconferenceasaspecialissueoftheirjournal.Dr.SpeddingdescribedsomeoftherecentactivityundertakenbyDr.OhlsteintoincreasethefrequencyofIUPHARpublicationsandreportedthatDr.OhlsteinhasbeenscheduledasoneoftheguestsduringtheMay16thofficerteleconference.TheIUPHARofficerswillexploretheoptionofrecruitingayounginvestigatortoserveasarepresentativeontheExecutiveCommitteeandmanagetheIUPHARsocialmediasitesThistopicwillbeundertakenclosertothe2018WorldCongressofBasicandClinicalPharmacology(WCP2018)inKyoto,Japan.TheIUPHARofficerswillsolicitproposalsfrommembersocietiestohosttheIUPHARExecutiveOffice,withasubmissiondeadlineofJune30th,2017.Thisactionisinprogresswithoneproposalreceivedthusfar.Ms.LeCountwillscheduleDr.Abernethyorhisdesigneeonallfutureofficerconferencecalls.Thisactionhasbeencompleted.Dr.BarrettwillinvestigatethepotentialbenefitsandfeasibilityofforminganIUPHARAcademicDrugDiscoverySectionandtoreporthisfindingsatthenextExecutiveCommitteemeeting.Dr.PatelcanprovidecontactinformationforcolleaguesattheIndianNationalAcademicCenterandDr.ZhaocanfurnishcontactinformationforcolleaguesintheareaofChineseacademicdrugdiscovery.InternationalUnionofBasicandClinicalPharmacology(IUPHAR)20142018ExecutiveCommitteeTeleconferenceMay9,2017Minutes 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Dr.BarretthasdiscussedwithMichelleLarkin,amongothercolleaguesinfield,thefeasibilityofestablishinganacademicdrugdiscoverysectionsowillreportfurtheronhisfindingsduringtheExecutiveCommitteemeetinginRimini.Dr.SpeddingwillcontactDr.LewisandDr.EnnawillcontactDr.J.R.HaywoodtoseektheiropinionsaboutthevalueofIUPHARpayingduestoICLAS.TheseactionshavebeencompletedandwillbeontheagendaoftheExecutiveCommitteemeetinginRimini.Dr.EnnawillnotifyDr.FredWong,thecurrentpresidentoftheSingaporeSociety,oftheiracceptanceasamemberofIUPHAR.Thisactionhasbeencompleted.Dr.EnnawillcommunicatewithDr.RothabouttheIUPHARLecturerinAnalyticalPharmacologyawardandhisinvitationtopresentaplenarylectureatthemeeting.Thisactionhasbeencompleted.VicePresidentMasamitsuIinoconfirmedthatDr.RothisnowlistedamongthespeakersontheWCP2018website.WorldHealthOrganization(WHO)collaborationplanforIUPHARNGOrenewalapplication(Spedding)Dr.SpeddingreportedthatDr.KalleHoppu,currentchairoftheIUPHARLiaisonCommitteetotheWorldHealthOrganizationwasaguestduringtheMarch14thofficerteleconferencesodiscussionshavebegunonthetypesofactivitiesIUPHARshouldincludeonaCollaborationPlantosubmitwiththeapplication.Dr.DarrellAbernethynotedthatwiththeexceptionoftheDr.Hoppu,theWHOliaisoncommitteemembershavenotbeenveryengaged.Hefeltthat,aspartoftheCollaborationPlanprocess,itwouldbeprudenttoidentifyIUPHARrepresentativeswillingtoreadtheWHOliteraturerelevanttoIUPHARandsuggestpossibleactionstomaintaintheNGOstatus.Dr.ThrmannhasbeenincommunicationwithDr.LembitRgo,aformerWHOemployee,toseekhisadviceonhowbesttocomposeaCollaborationPlanthatwillappealtotheWHONGOreviewboard.Dr.SpeddingfeelsthatmanyofthecurrentIUPHARinitiativesarealreadyinlinewiththeWHOgoal.Dr.EnnawonderedwhethertheupcomingclinicalworkshopsinChinawouldqualifyinthisregard.CouncilorYongxiangZhangsummarizedarecentvisittoBeijingbyDr.Abernethytovisittheworkshopfacilitiesandreviewtheproposedcurriculumwiththeorganizers.Dr.AbernethynotedthatthesuccessofChinaindevelopingscienceandtechnologynolongerqualifiesthemasadevelopingcountryundertheWHOmission.Dr.EnnaencouragedDr.ZhangandhiscolleaguestocommunicatewiththeIUPHARClinicalPharmacologyDivisionandtheAmericanSocietyofPharmacologyandExperimentalTherapeuticstoidentifyinitiativesinthedevelopingareasofAsiawhereIUPHARcanofferassistanceinlinewiththeWHOgoals.PastPresidentPatrickduSouichsuggestedtheinitiativesalsoincludetheAustralasianSocietyofClinicalandExperimentalPharmacologistsandToxicologists,notingtheoutstandingeffortsinthisregardbyDr.TonySmithandhiscolleagues.Dr.EnnaencouragedDrs.SpeddingandCouncilorBhagirathPateltoexploresimilaropportunitiesforIUHARinteractionswhileDr.SpeddingisvisitingIndialaterthisyear.Dr.Patelreportedsomeinteractionshavealreadybeenundertaken,citingtherecentexampleoftheworkshopinMumbaicoorganizedbyDr.MilouDanielDrici,chairoftheIUPHARPharmacoepidemiologyandPharmacovigilanceSubcommittee,togetherwiththeSouthAsianCollege,anaffiliateoftheAmericanCollegeofClinicalPharmacology.Dr.PatelfeelstheseareexcellentmechanismsforimprovingthehealthcaredeliverywhilemeetingtheWHOgoals.ThistopicwillbeontheagendaoftheExecutiveCommitteemeetinginRimini.OctobermeetingsinRimini,ItalyDr.EnnasummarizedthediscussiontopicssuggestedthusfarduringtheteleconferencethatwillbeincludedontheOctoberagenda.Thestandardfinanceandactivityreportswillbecovered.HealsoraisedanissuesuggestedbyVicePresidentDavidWebbfollowingthe2014GeneralAssemblyofestablishingsecurevotingproceduresfortheIUPHARdelegates.InternationalUnionofBasicandClinicalPharmacology(IUPHAR)20142018ExecutiveCommitteeTeleconferenceMay9,2017Minutes 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Asinpastyears,theExecutiveCommitteememberswillreceiveatravelstipendtowardstheirexpensesinparticipatingintheRiminimeeting.Dr.Ennaexplainedindeterminingtheamounts,Ms.Arbuckletookintoaccountforeachregionthecostofroundtripairfare,numberofhotelnightsneededbeyondthosebeingprovidedbythemeetinghosts,theItalianPharmacologicalSociety,andgroundtransportationneeds.Ms.LeCountrecentlylearnedthatsincethe38thNationalCongressoftheItalianSocietyofPharmacology(http://congresso.sifweb.org)isbeingheldOctober25th28th,thefreemeetingfacilitiesareonlyavailabletotheIUPHARExecutiveCommitteeonthesedates.CouncilorEevaMoilanen,Dr.ZhangandDr.duSouichencouragedtheofficerstomeetatthebeginningoftheItalianCongressduetocompetingobligationsontheircalendars,however,severalotherExecutiveCommitteemembersreportedconflictsontheearlierdates.ItwasultimatelydecidedtoreschedulethemeetingsduringtheafternoonofFriday,October27thandalldayonSaturday,October28th.Dr.BarrettinquiredwhetherparticipationintheItalianCongressismandatoryforExecutiveCommitteemembers.Dr.Ennaclarifiedthatitisnot,notingthatmanyofthelecturesarelikelytobeinItalian.Ms.LeCountwilldistributeadditionaldetailsastheybecomeavailable.Otherbusiness/closingremarksDr.SpeddingintroducedaproposaltohosttheIUPHARExecutiveOfficerrecentlyreceivedfromtheParthenonManagementGroup,aspinoffoftheAmericanCollegeofNeuropsychopharmacologytoprofessionallymanagescientificsocieties.Theproposaloffersupto100hoursofservicepermonthandincludesnearlyallofthetasksanddutiescurrentlybeingperformedbyMs.LeCountandMs.ArbuckleforanannualfeeofUS$75kexcludingsundryoperationalexpenses,suchaslongdistancescharges,postage,photocopying,travel,etc.TheyarepreparedtohaveanIUPHARExecutiveOfficerhiredbyspring2018sothatthetransitionwithinafewweeksofthe2018WorldCongresswillbeseamless.Dr.WebbobservedthattheannualmeetingoftheAmericanCollegeofNeuropsychopharmacologyiswellrunandDr.Ennaconfirmeditsthesamegroupofpeople.ThepossibilityofreceivingproposalsfromsomeofthelargerIUPHARmembersocietieswasdiscussedbutnoneappeartobeforthcomingatthispoint.Ms.LeCountnotedthatafinalreminderwillbesentatthebeginningofJunetoallIUPHARmembersocietiesthatthedeadlineforsubmittingproposalsistheendofJune.ThegroupcompiledalistquestionsandclarificationstocommunicatetotheParthenonManagementGroupandtheirresponseswillbediscussedinconjunctionwiththeproposalduringthemeetinginOctober.Dr.Speddingdescribedanewinitiative,whichmayleadtofuturefundingopportunities.KarolinskaInstitute(KI)hasshownthattherearemajorchangesindrugmetabolismformanydrugsbetweendifferenthumanpopulations,whichechoarecentcommentary,featuringCollenMasarimabwaaleadingmemberofPharfA,inNatureonthemetabolismofdrugsforAIDS.ApreliminaryinteractionbetweenKIandNCIUPHARhasshownthatdrugtargetsmayalsobemodifiedbetweendifferentpopulations,whichispotentiallyofgreatinteresttoworldhealth.ThiswouldbeofgreatuseifthetargetscouldbeenlargedtotheWHOessentialdrugslist.Dr.SpeddinghopestoidentifymajordrugtargetsthatmaybeusedtoattractgrantfundingfortheIUPHARPharmacogeneticsandPharmacogenomicsSectioninadditiontothePharmacologyforAfricainitiative.HenotedthatthiswouldincludecollaborationopportunitiesfortheChinesePharmacologicalSocietyandtheIndianSocietyofPharmacology.Dr.Ennacalledforquestionsorcommentsand,astherewerenone,concludetheteleconferenceat8:05a.m.CDT.LynnLeCount,CMAAdministrativeOfficer

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