Thymidine synthesis Purines dUMP 5. 10 Methylene THF Tryptophan Arginine BH4 ALUM Tyrosine glycine THF Methionine glycine MAT SAMe DMG Guanido AC Creatine Creatinine Pyruvate SHMT serine mercury lead B12 MTRR BHMT TMG methylation SAH adenosine DNA, RNA Protein, lipids MTR SAH Acetyl CoA oxaloacetate aspartate Ornithine ACAT citrate UREA AMMONIA NOS LEAD DHPR BH2 MTHFR 5 Methyl THF AHCY Homocysteine 2 BH4 fumarate Kreb’s Cycle isocitrate α-ketoglutarate OTC CBS VDR cystathionine succinate NADH/FADH Serotonin Dopamine NorEp SAMe AMMONIA Cysteine + , α-ketobutyrate taurine glutathione MAO A Citrulline + NO Neuronal Damage 1 BH4 HIAA COMT HVA SAH Peroxynitrite 0 BH4 COMT VMA SAH Microglial Activation Super Oxide “When the need is for energy and not for cysteine, homocysteine is metabolized to Alpha-Ketobutyrate, NH3 and H2S.” Text of Biochemistry with Clinical Correlations, Devlin 2002 GST SOD G6PDH glutamate gaba SUOX cortisol ACE Angiotensin I Angiotensin II Yasko Methylation Pathway © Content and diagrams may not be reproduced without express permission from NRI and HHI GAD
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Yasko Methylation Cycle

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Here is the updated diagram of the methylation cycle that I utilize in the program. For additional information about the cycle go to the Methylation and Mutation DVDs on www.dramyyasko.com/resources. For specific questions I suggest going to the chat group at www.ch3nutrigenomics.com.

With love and hope, Dr. Amy


© Content and diagrams may not be reproduced without express permission from NRI and HHI
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Thymidine synthesis Purines dUMP 5. 10 Methylene THF Tryptophan Arginine BH4 ALUM Tyrosine glycine THF Methionine glycine MAT SAMe DMG Guanido AC Creatine Creatinine Pyruvate SHMT serine mercury lead B12 MTRR BHMT TMG methylation SAH adenosine DNA, RNA Protein, lipids MTR SAH Acetyl CoA oxaloacetate aspartate Ornithine ACAT citrate UREA AMMONIA NOS LEAD DHPR BH2 MTHFR 5 Methyl THF AHCY Homocysteine 2 BH4 fumarate Kreb’s Cycle isocitrate α-ketoglutarate OTC CBS VDR cystathionine succinate NADH/FADH Serotonin Dopamine NorEp SAMe AMMONIA Cysteine + , α-ketobutyrate taurine glutathione MAO A Citrulline + NO Neuronal Damage 1 BH4 HIAA COMT HVA SAH Peroxynitrite 0 BH4 COMT VMA SAH Microglial Activation Super Oxide “When the need is for energy and not for cysteine, homocysteine is metabolized to Alpha-Ketobutyrate, NH3 and H2S.” Text of Biochemistry with Clinical Correlations, Devlin 2002 GST SOD G6PDH glutamate gaba SUOX cortisol ACE Angiotensin I Angiotensin II Yasko Methylation Pathway © Content and diagrams may not be reproduced without express permission from NRI and HHI GAD
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