Analyte Quarterly 2012Q4

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The broadest selection of analytes acrossa wide range of disease states, including metabolic disease, inflammation, neurodegenerative disease, toxicity,cancer and more. All the components and reagents you need to detect multiple analytes simultaneously in a small sample size (10-50 L)all in a single kit, using a single catalogue number.


Immunoassays & MILLIPLEX map KitsThe #1 Best Seller for Multiplexing using Luminex technologyAnalyte Quarterly Q4 2012 Bone Metabolism DiseaseCancer Cell Signaling Metabolism Cardiovascular Cellular Inflammation/Immunology Metabolism Stem Cell Characterization Neuroscience ToxicityEMD Millipore is a division of Merck KGaA, Darmstadt, GermanyThe Latest in Multiplexing & ELISAsDiscover the Latest in Innovative and Unique Assay Kits, Instruments and ServicesMILLIPLEX map Multiplex Immunoassay KitsMagnetic Bead FormatKit Cancer/Metastasis Panel Biomarker 1 Early Apoptosis Signaling - 7 Plex Kidney Toxicity Panel 1 Late Apoptosis Signaling - 3 Plex MAPK/SAPK Signaling - 10 Plex Neurodegenerative Disease Panel 2 Cytokine/Chemokine Cytokine/Chemokine - 13 Plex Premix Soluble Cytokine Receptor Src Family Kinase Active Site - 8 Plex Stem Cell Pluripotency Panel 1 T-Cell Receptor - 7 Plex Th17 - 25 Plex Premix Human Human Human Porcine Porcine Mouse Canine Human Species Human Catalogue No. HCMBMAG-22K 48-669MAG CKTX1MAG-97K 48-670MAG 48-660MAG HNDG2MAG-36K PCYTMAG-23K PCYTMG-23K-13PX MSCRMAG-42K 48-650MAG 48-617MAG 48-690MAG HT17MG-14K-PX25NEW PA NEL SELISA Kits Cytokine ELISAs FGF-23 (Rat / Mouse) - 10-pack Glucagon (Human / Rat / Mouse) Glucagon (Human / Rat / Mouse) - 10-pack GLP-1 HS (Active) (Multispecies) - 10-pack GLP-2 (Total) (Rat / Human) - 10-packMAGPIX Instrument Multiplex analyte detection system (See page 21)Services Biomarker Services (See back cover)New MILLIPLEX Analyst 5.1 Software!You asked for new and enhanced features and we listened! Our new software provides you with the data you need, combining speed and accuracy, even at the lowest part of the curve. For details, see page 22.20% OFFMILLIPLEX Analyst 5.1 Software one- or five-seat licenses now through December 31, 2012(Use promo code ZBIOS584)NEW PRO DU CT SPOTLIG H TMILLIPLEX MAP & ELISAs New Product SpotlightImmunology: MILLIPLEX MAP Human and Mouse(Cat. No. HTH17MAG-14K) (Cat. No. MTH17MAG-47K)Discover the most versatile assay platform for autoimmune disease and immunology research. T-cell differentiation and cytokine secretion regulate immune response, chronic inflammation, autoimmune diseases and cancer. Get the most information from each sample with our HumanMouse Plasma Cytokines600 Plasma Levels (pg/mL) 400 300 200 100 0 0 1 IL-13 2 Time after LPS (hr) IL-17F 4 IL-17A 8 Plasma Levels (pg/mL) 500 9000 8000 7000 6000 5000 4000 3000 2000 1000 0and Mouse Th17 panels that enable you to quantify signature cytokines from not only Th17 cells but, Th1 and Th2 cell subsets as well. With this broader analytical scope, you can expand each experiment beyond Th17 cytokines.Mouse Plasma CytokinesFigure 1A and 1B. Examination of cytokine response in mouse plasma at various time points after an in vivo LPS-challenge.8 IFN0 IL-61 IL-222 Time after LPS (hr) TNF4 IL-10Cell Signaling: MILLIPLEX MAP TGF Pathway 6-Plex Panel(Cat. No. 48-614MAG)Understanding regulation of the TGF signaling network requires simultaneous analysis of multiple, mutually interacting signaling proteins. The MILLIPLEX MAP TGF Pathway 6-Plex Panel, based on the Luminex xMAP technology, moves your research faster by enabling you to quantify multiple Smads and other TGF pathway proteins simultaneously. Use Iess sample. Get more data. Better data than you ever got from Western blotting! Advantages of MILLIPLEX MAP Cell Signaling Kits over traditional cell signaling assays:4000 4000 3000MFIAnalyze dozens of samples using a 96-well plate Analyze time course or dose response curves, alI in one assay Measure concentrations of multiple total or phosphorylated proteins in the same well Use median fluorescence intensity to measure fold increases comparing stimulated and unstimulated cell cultures or tissue lysates Validated using Western blotting and IPFigure 2A and 2B. TGF pathway proteins were simultaneously detected in two sets of human tissue samples (20 g/well). PhosphoSmad2 was significantly elevated in breast cancer tissue samples.Breast Normal 2 Breast Cancer 2Breast Normal 1 Breast Cancer 1 MFI300020002000 1000 0For Research Use PRO DUCT SPOTLIGH TToxicity: MILLIPLEX MAP Rat Kidney Toxicity Magnetic Bead Panel 1(Cat. No. RKTX1MAG-37K)Toxicity is the leading cause of drug failure, so increasing the success rate of therapeutic development requires more sensitive and rapid methods to determine organ-specific damage. The traditional tests to determine kidney toxicity are blood urea nitrogen (BUN) and serum creatinine (SCr), which are not optimal for early detection or localization of kidney damage. As a result, researchers have turned to recently qualified nephrotoxicity biomarkers for more predictive toxicity analysis. We have developed the MILLIPLEX MAP Rat Kidney Toxicity MagneticClusterin1000 900 800 700 600 500 400 300 200 100 0 H2O low dose gentamicin high dose gentamicin ng/mL 10.0 9.0 8.0 7.0 6.0 5.0 4.0 3.0 2.0 1.0 0.0Bead Panels 1 and 2, containing a total of 14 kidney toxicity biomarkers. We used these panels to efficiently profile response to gentamicin, a known nephrotoxicant in rats. By simply measuring biomarker concentrations in urine, we detected kidney toxicity (marked by increased Clusterin and KIM-1 levels) in as few as three days (Figure 3).Figure 3A and 3B. 3 groups of 5 adult male Sprague Dawley rats, each injected intraperitoneally daily with either water, low-dose (70 mg/kg) gentamicin or high-dose (140 mg/kg) gentamicin. Day 0 urine collection is after the 1st dose, and subsequent collections are at days 3, 7 and 14. All KIM-1 nephrotoxicity biomarkers H2O were analyzed, but we low dose gentamicin show data here only for high dose gentamicin Clusterin and KIM-1. Analyte concentrations in gentamicin treated animals spike at day 3 for both Clusterin and KIM-1, and decrease at days 7 Day 3 Day 7 Day 14 and 0Day 3Day 7Day 14Day 0Metabolism: ELISA - Circulating Glucagon(Cat. No. EZGLU-30K) (Cat. No. EZGLU-30BK)Glucagon is the most important counterregulatory hormone to insulin in blood glucose homeostasis. It stimulates gluconeogenesis and glycogenolysis while inhibiting glycogenesis and glycolysis mainly in the liver. Recently, glucagon and its receptors have been actively pursued as therapeutic targets for Type I diabetes. However, quantifying glucagon in blood has been challenging due to glucagons many immunoreactive forms.100 10 4 Sample Results Using ACN Extraction, pg/ml 80EMD Millipores new, highly specific glucagon ELISA kit shows no cross-reactivity to miniglucagon or glucagon 118 and < 5% cross-reactivity to oxyntomodulin. This assay, including sample extraction using our rapid protocol (Figure 4B), can be completed within a working day. In contrast to kits from competing suppliers, results from our ELISA kit agree well with published glucagon levels.Figure 4. A. EMD Millipores Glucagon ELISA (Cat. No. EZGLU-30K) kit exhibits sensitive, precise detection of full length, porcine glucagon with low interassay variation. B. Correlation of glucagon measurements following sample extraction using rapid acetonitrile extraction (y-axis) with measurements following extraction using solid phase extraction (x-axis).RLU (Mean S.D., n=5)6010 340For Research Use Only.Y = 1.024(x) + 2.06 r = 0.903 n = 2110 2 0.01 0.1 1 Porcine Glucagon, ng/ml Standard Curve Assay Background200020 40 60 80 100 Sample Results Using Waters HLB Extraction Plate, pg/ml2ELISAs & RIAsEMD Millipore provides an unparalleled level of peer supportscientists working with scientiststo provide you with the quality tools and services you need to do your best work. With a wide range of ELISAs and RIAs, we advance your research in many research areas including metabolic disease (diabetes, obesity, cardiovascular), inflammation, immunology, neuroscience, oncology and cell signaling. Plus, some of our most popular ELISAs are available a 10-pack format. ELI S A / RI A*Cytokine ELISAsKit IL-2 IL-2 IL-4 IL-4 IL-6 IL-6 IL-10 IL-10 TNFa TNFa Species Human Mouse Human Mouse Human Mouse Human Mouse Human Mouse Catalogue No.NEW! NEW! NEW! NEW! NEW! NEW! NEW! NEW! NEW! NEW!Neuroscience ELISAs, continuedKit Neuropeptide Y (NPY) Neuropeptide Y (NPY) Phosphorylated Neurofilament (pNF-H) Pigment Epithelium Derived Factor (ChemiKine) S100B SAA-3 Species Human Rat/Mouse Multispecies Human Catalogue No. EZHNPY-25K EZRMNPY-27K NS170 CYT420 EZHIL2 EZMIL2 EZHIL4 EZMIL4 EZHIL6 EZMIL6 EZHIL10 EZMIL10 EZHTNFA EZMTNFAHuman MouseEZHS100B-33K EZMSAA3-12KELISA Circulating BiomarkersKit Adiponectin 10 - Pack Species Human Mouse Rat Canine Human Catalogue No. EZHADP-61K EZHADP-61BK EZMADP-60K EZMADP-60BK EZRADP-62K EZCADP63K EZHMWA-64K EZHMWA-64BK Mouse Human Human Human Human/Rat Human Human Rat/Mouse Human Rat Canine Human Rat/Mouse EZMADPSN-22 EZHA-52K EZHA-52BK EZHAT-51K EZHAPOA4-73K CYT306 EZHCMRN-57K EZHCP-20K EZHCP-20BK EZRMCP2-21K CYT298 CYT294For Research Use Only.* 10-Pack Format Now Available for Select Kits!Neuroscience ELISAsKit a-Synuclein Amyloid Beta, 1-40 Amyloid Beta, 1-42 Amyloid Beta, SET Amyloid Beta (Brain), 1-40 Amyloid Beta (Brain), 1-42 Amyloid Beta (Brain), SET Brain Derived Neurotrophic Factor (ChemiKine) Glial fibrillary acidic protein (GFAP) Nerve Growth Factor (ChemiKine) Neuropeptide S (NPS) Species Human/Rat/ Mouse Human Human Human Human Human Human Human/Rat Catalogue No. NS400 EZHS40 EZHS42 EZHS-SET EZBRAIN40 EZBRAIN42 EZBRAIN-SET CYT306Adiponectin 10 - Pack Adiponectin Adiponectin Adiponectin High Molecular Weight 10 - Pack Adipsin Amylin (active) 10 - Pack Amylin (total) Apo AIV BDNF Chemerin C-Peptide 10 - Pack C-Peptide 2 CRP CRP CRP FGF-21 FGF-21Human/Rat/ Mouse Rat/Mouse HumanNS830 CYT304 EZHNPS-34KCYT296 EZHFGF21-19K Circulating Biomarkers, continuedKit FGF-23 10 - Pack FGF-23 10 - Pack FGF-23 10 - Pack Species Human RatNEW!Catalogue No. EZHFGF23-32K EZHFGF23-32BK EZRFGF23-42K EZRFGF23-42BKKit Procollagen Type IIA N-Propeptide (PIIANP) Proinsulin (Intact) Proinsulin (total) 10 - Pack PYY (total) 10 - Pack RBP4 Resistin 10 - PackSpecies Human Human Human Human Human HumanCatalogue No. EZPIIANP-53K EZHIPI-17K EZHPI-15K EZHPI-15BK EZHPYYT66K EZHPYYT-66BK EZHRBP4-18K EZHR-95K EZHR-95BKMouse Human Rat/Mouse Human Rat Human Rat/Mouse Multispecies MultispeciesEZMFGF23-43K NEW! EZMFGF23-43BK EZGRA-88K EZGRA-88BK EZRGRA-90K EZGRT-89K EZGRT-89BK EZRGRT-91K EZHGIP-54K EZHGIP-54BK EZRMGIP-55K EZRMGIP-55BK EGLP-35K EGLP-35BK EZGLPHS-35KNEW!ELI S A / RI AGhrelin (active) 10 - Pack Ghrelin (active) Ghrelin (total) 10 - Pack Ghrelin (total) GIP (total) 10 - Pack GIP (total) 10 - Pack GLP-1 (active) 10 - Pack GLP-1 High Sensitivity (active) 10 - Pack GLP-1 (total) 10 - Pack GLP-2 (total) 10 - Pack Glucagon 10 - Pack Growth Hormone 10 - Pack IFNa Insulin 10 - Pack Insulin 10 - Pack Laminin Leptin Dual Range 10 - Pack Leptin 10 - Pack Leptin 10 - Pack Leptin Nerve Growth Factor (ChemiKine) Omentin-1 Pancreatic Polypeptide 10 - Pack PEDF (ChemiKine)For Research Use Only.ELISA Other AssaysEZ-Transcription FactorDescription AP-1 Family c-Fos c-Jun ErbB2 (Tyr1248) HDAC Jun/Fos NFkB Family NFkB p50 NFkB p50/p65 NFkB p65 PI3 Kinase Activity/Inhibitor PhosphaFluor HTS OmniPhosphatase Ras Activation ssDNA Apoptosis Universal TF Colorimetric Catalogue No. 70-550 70-545 70-540 17-490 17-374 70-546 70-560 70-515 70-510 70-520 17-493 17-448 17-497 APT225 70-501 70-601 70-646 70-660 70-615 70-610 70-620 Chemiluminescent Catalogue No. 70-650 70-645 70-640EZGLPHS-35K EZGLP1T-36K EZGLP1T-36BKMultispecies Human/RatNEW!EZGLP2-37K EZGLP2-37BK EZGLU-30K EZGLU-30BK EZRMGH-45K EZRMGH-45BK Cyt271 EZHI-14K EZHI-14BK EZRMI-13K EZRMI-13BK EZHIASF-14K ECM310 EZHL-80SK EZHL-80BK EZML-82K EZML-82BK EZRL-83K EZRL-83BK EZCL-31K CYT304Human/Rat/ Mouse Rat/Mouse Human Human Rat/MouseNEW! NEW!Insulin (Animal Serum Free) Human Human Human Mouse Rat Canine Rat/Mouse Human Human HumanELISA Other AssaysExtracellular MatrixKit Fibronectin sCD26 sE-Selectin sICAM-1 sICAM-2 sICAM-3 sL-Selectin sVCAM-1 Species Human Human Human Human Human Human Human Human Catalogue No. ECM300 ECM345 ECM330 ECM335 ECM346 ECM337 ECM331 ECM340EZH0MNTN1-29K EZHPP40K EZHPP-40BK CYT420* Coming Soon Solid Plate Format CU.S. Patent #: 5,541,066: 5,780,240 Requires Sample Extraction4ELISA Cell Signaling / IntracellularStar ELISAsDescription AKT1 (total) EGFR (total) Erk 1/2 (total) FAK (total) Insulin Receptor ( subunit) (total) IkB (total) JNK 1/2 (total) MEK1 (total) Met (total) p38a (total) PRAS40 (total) Src (total) phospho-Akt (Ser473) phospho-Akt (Thr308) phospho-EGFR (Tyr1068) phospho-EGFR (Tyr1173) phospho-FAK (Tyr397) phospho-IR ( Subunit) (Tyr 1162/1163) phospho-IRS1 (Ser307 mouse/Ser312 Human) phospho-IkB (Ser32) phospho-JNK 1/2 (Thr183/Tyr185) phospho-MEK1 (Ser218/222) phospho-MET (Tyr1230/Tyr1234/Tyr1235) phospho-p38a (Thr180/Tyr182) phospho-p53 (Ser15) phospho-PRAS40 (Thr246) Catalogue No. 17-455 17-460 17-463 17-479 17-483 17-485 17-465 17-473 17-469 17-487 17-477 17-467 17-457 17-456 17-462 17-461 17-480 17-484 17-459 17-486 17-466 17-474 17-470 17-488 17-475 17-478continuedKitFormerly EMD Chemicals ELISAs,Species Human Human Human Multi-species Human Human Human Human Human Human Mouse Human Catalogue No. QIA96 QIA61 QIA54 QIA40 QIA99 QIA52 QIA23 QIA29 CBA053 CBA071 QIA10 PMN Elastase/a1-PI Complex TGFa TIMP-1 TIMP-2 Soluble t-PA VEGF Total Bcl-2 Cathepsin D (Rapid Format) COX-2 Total CREB Total c-ErbB2/c-Neu (Rapid Format) PhosphoDetect ERK1/2 (Thr185/Tyr187)ELIS A / RIAHuman Rat MouseCBA006For technical support and ordering, visit: Adiponectin Adiponectin C-Peptide C-Peptide C-Peptide C-Peptide Ghrelin (active) Ghrelin (total) GLP-1 (active) GLP-1 (total) Glucagon Insulin Insulin Insulin Lispro Insulin Specific Insulin Ultra Sensitive Insulin Leptin Leptin Leptin Leptin Proinsulin PYY PYY (3-36) Specific PYY (total) Human Human Rat Human Mouse Rat Multi-species Human Rat/Mouse Human Human Species Human Mouse Human Rat Canine Porcine Human Human Multi-species Multi-species Multi-species Rat Porcine Catalogue No. HADP-61HK MADP-60HK HCP-20K RCP-21K CCP-24HK PCP-22K GHRA-88HK GHRT-89HK GLP1A-35HK GLP1T-36HK GL-32K RI-13K PI-12K LPI-16K HI-14K HI-11K SRI-13K HL-81K ML-82K RL-83K XL-85KFor Research Use Only.ELISA Cell-based AssaysDual Detect CELISAsDescription ErbB2 (Tyr1248) H2A.X (Ser139) Catalogue No. 17-490 17-720Formerly EMD Chemicals ELISAsKit Frataxin FasL Galectin-3 Lactoferrin MMP-1 MMP-2 MMP-9 MMP-13 Myeloperoxidase Species Human Human Human Human Human Human Human Human Human Catalogue No. EAMT002 QIA27 QIA112 427275 QIA55 QIA63 QIA56 QIA130 475919HPI-15K RMPYY-68HK PYY-67HK PYYT-66HK5CIRCU L ATINGMILLIPLEXmapM I LLI PLEX Your Source for Simultaneous Multi-Analyte Detection the Voice of Luminex xMAP Technology The broadest selection of analytes across a wide range of disease states, including metabolic disease, inflammation, neurodegenerative disease, toxicity, cancer and more. All the components and reagents you need to detect multiple analytes simultaneously in a small sample size (10-50 L)all in a single kit, using a single catalogue number. Available in a magnetic bead format. Magnetic polystyrene beads contain encapsulated magnetite with bead surface chemistries that are comparable to nonmagnetic beads. New magnetic bead panels will be introduced into our portfolio each quarter! Select a premixed kit or choose analytes within a panel to design a custom kit. Quality controls provided to qualify assay performance. Analytically validated panels that yield consistent analyte profiles irrespective of plex size. Standardized standard curve ranges across analytes and lots to ensure lot-to-lot consistency. Panels meet stringent manufacturing criteria to ensure batch-to-batch reproducibility. Environmentally friendly packaging: our boxes are 100% recyclable to reduce ecological footprints. Consolidated packaging available for larger orders to reduce storage needs.For Research Use Adipokine Panel 1Serum/Plasma Samples (Cat. No. HADK1MAG-61K)Adiponectin Adipsin Lipocalin-2/NGAL PAI-1 (total) ResistinM ETA BO LISMRat AdipocyteCell culture samples (Cat. No. RADPCYT-82K)Adiponectin IL-1 IL-6 Leptin MCP-1 PAI-1 (active) PAI-1 (total) TNFaNon-Human Primate Metabolic Hormone(Cat. No. NHPMHMAG-45K)Amylin (active) C-Peptide Ghrelin (active) % GIP (total) GLP-1 (active) Glucagon IL-6 Insulin Leptin MCP-1 Pancreatic Polypeptide PYY (total) TNFaHuman Adipokine Panel 2Serum/Plasma Samples (Cat. No. HADK2MAG-61K)HGF IL-1 IL-6 IL-8 Insulin Leptin MCP-1 NGF TNFaHuman Metabolic Hormone(Cat. No. HMHMAG-34K)Amylin (active) Amylin (total) C-Peptide Ghrelin (active) % GIP (total) GLP-1 (active) Glucagon IL-6 Insulin Leptin MCP-1 Pancreatic Polypeptide PYY (total) TNFaHuman Liver Protein(Cat. No. HLPPMAG-57K)AFP ANGPTL3 ANGPTL4 ANGPTL6 FABP1 FGF-19 FGF-21 FGF-23 HGFHuman AdipocyteCell Culture Samples (Cat. No. HADCYMAG-61K)Adiponectin HGF IL-1 IL-6 IL-8 Leptin MCP-1 NGF PAI-1 (total) Resistin TNFaMIL L IPL EX m a p CIRCUL AT INGMouse Metabolic Hormone(Cat. No. MMHMAG-44K)Amylin (active) C-Peptide 2 Ghrelin (active) % GIP (total) GLP-1 (active) Glucagon IL-6 Insulin Leptin MCP-1 Pancreatic Polypeptide PYY (total) Resistin TNFaHuman Gut Hormone(Cat. No. HGT-68K)Amylin (active) Amylin (total) Ghrelin (active) % GIP (total) GLP-1 (active) Insulin Leptin Pancreatic Polypeptide PYY (total)Mouse AdipokineSerum/plasma samples (Cat. No. MADPK-71K) MB Format Coming Soon*IL-6 Insulin Leptin MCP-1 PAI-1 (total) Resistin TNFaMouse Gut Hormone(Cat. No. MGT-78K)Amylin (active) Leptin Pancreatic Polypeptide PYY (total) Ghrelin (active) % GIP (total) GLP-1 (active) InsulinRat Metabolic Hormone(Cat. No. RMHMAG-84K)Amylin (active) C-Peptide 2 Ghrelin (active) % GIP (total) GLP-1 (active) Glucagon IL-6 Insulin Leptin MCP-1 Pancreatic Polypeptide PYY (total) TNFaMouse AdipocyteCell culture samples (Cat. No. MADPCYT-72K) MB Format Coming Soon*Adiponectin IL-6 Leptin MCP-1 PAI-1 (total) Resistin TNFaRat Gut Hormone(Cat. No. RGT-88K)Amylin (active) Ghrelin (active) % GIP (total) GLP-1 (active) Insulin Leptin Pancreatic Polypeptide PYY (total)Rat AdipokineSerum/plasma samples (Cat. No. RADPK-81K)IL-1 IL-6 Insulin Leptin MCP-1 PAI-1 (active) PAI-1 (total) TNFaNEW!Canine Gut Hormone(Cat. No. CGTMAG-98K)Amylin (total)% Requires a protease inhibitor during sample collection Cannot be plexed together: 1) Amylin (active) and Amylin (total) 2) PAI-1 (active) and PAI-1 (total) Non-magnetic bead formatInsulin Leptin Pancreatic Polypeptide PYY (total)For Research Use Only.Ghrelin (active) % GIP (total) GLP-1 (active) Glucagon7META BO LI SM / BO NE M ETA BO LISMMetabolism(Cat. No. HPTP1MAG-66K)ACTH AGRP CNTF FSH GH LH TSHBone MetabolismRat Stress Hormone(Cat. No. RSH69K)ACTH Corticosterone MelatoninHuman Pituitary Panel 1Human Bone Panel(Cat. No. HBNMAG-51K)ACTH DKK1 FGF-23 IL-1 IL-6 Insulin Leptin OPG Osteocalcin Osteopontin PTH SOST TNFaHuman Pituitary Panel 2(Cat. No. HPTP2MAG-66K)BDNF ProlactinMulti Species Steroid/ Thyroid Hormone(Cat. No. STTHMAG-21K)Cortisol Estradiol Progesterone T3 T4 Testosterone*nNon-Human Primate Pituitary Panel 1(Cat. No. NHPPT1MG-46K)ACTH GH LH TSH AGRP CNTF FSHHuman Bone Panel 1ASerum/plasma samples (Cat. No. HBN1A-51K)ACTH Insulin Leptin OPGHuman IGF Binding Protein(Cat. No. HIGFBP-53K) MB Format Coming Soon*IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7**Osteocalcin Osteopontin PTHMIL L IPL EX m a p CIRCUL AT INGNon-Human Pituitary Panel 2(Cat. No. NHPPT2MG-46K)BDNF ProlactinHuman Bone Panel 1BTissue culture samples Cat. No. HBN1B-51K)ACTH Adiponectin IL-1 IL-6 Insulin MADPK-71K-ADPN RADPK-81K-ADPN RMIGF187K Leptin OPG Osteocalcin Osteopontin PTH TNFaMouse IGF Binding Protein(Cat. No. MIGFBPMAG-43K)IGFBP1 IGFBP2 IGFBP3 IGFBP5 IGFBP6 IGFBP7**Mouse Pituitary(Cat. No. MPTMAG-49K)ACTH BDNF FSH GH LH Prolactin TSHSingle Plex KitsAdiponectin (Mouse) Adiponectin (Rat) IGF-1 (Mouse/Rat) IGF-1 (Human)**nMouse Bone Panel 1ASerum/plasma samples (Cat. No. MBN1A-41K)ACTH IL-6 Leptin OPG TNFaRat Pituitary(Cat. No. RPTMAG-86K)ACTH BDNF FSH GH LH Prolactin TSHHuman IGF(Cat. No. HIGFMAG-52K)IGF-1 (Human)*nNEW!nInsulinIGF-2 (Human)*Mouse Bone Panel 1BTissue culture samples (Cat. No. MBN1B-41K)ACTH IL-6 Insulin Leptin OPG Osteocalcin TNFaCanine Pituitary N(Cat. No. CPTMAG-96K)ACTH BDNF FSH GHFor Research Use Only.LH Prolactin TSH8CardiovascularMouse Bone Panel 2ASerum/plasma samples (Cat. No. MBN2A-41K)ACTH IL-6 Insulin Leptin RANKL TNFaBO NE M ETA BO LISM / CV DHuman CVD Panel 1(Cat. No. HCVD1MAG-67K)BNP NT proBNP CK-MB CXCL6/GCP-2 CXCL16 Endocan-1 (ESM-1) FABP3 FABP4 LIGHT Oncostatin (OSM) Placental Growth Factor (PIGF) Troponin I (TnI)Human CVD1(Cat. No. HCVD1-67AK)MMP-9 MPO PAI-1 (total) sE-Selectin slCAM-1 sVCAM-1Mouse Bone Panel 2BTissue culture samples (Cat. No. MBN2B-41K)ACTH IL-6 Insulin Leptin Osteocalcin RANKL TNFaHuman CVD2(Acute phase proteins) (Cat. No. HCVD2-67BK)CRP Serum Amyloid PHuman CVD Panel 2(Cat. No. HCVD2MAG-67K)ADAMTS13 GDF-15 D-dimer sICAM-1 MPO Myoglobin Lipocalin-2/NGAL Serum Amyloid A sVCAM-1 sP-SelectinHuman CVD3(Cat. No. HCVD3-67CK)IFN IL-1 IL-6 IL-8 IL-10 MCP-1 NT-proBNP TNFa VEGFRat Bone Panel 1(Cat. No. RBN1-31K)ACTH Insulin Leptin OPGRat Bone Panel 2(Cat. No. RBN2-31K)ACTH Insulin Leptin RANKLHuman CVD Panel 3 (Acute Phase)(Cat. No. HCVD3MAG-67K)a-2-Macroglobulin Haptoglobin Adipsin AGP CRP Fetuin A Fibrinogen sL-Selectin Platelet Factor 4 (PF4) Serum Amyloid P von Willebrand FactorHuman Apolipoproteins(Cat. No. APO-62K) MB Format Coming Soon*Apo AI Apo AII Apo B Apo CII Apo CIII Apo ERat Bone Panel 3(Cat. No. RBN3-31K)Osteocalcin Osteopontin PTHMouse CVD1(Cat. No. MCVD1-77AK) MB Format Coming Soon*MMP-9 PAI-1 (total) sE-Selectin slCAM-1 sVCAM-1Single Plex Bone KitsOsteocalcin (Mouse) MBN-41K-1OC Osteocalcin (Rat) RANKL (Human) RANKL (Mouse) RANKL (Rat) OPG (Mouse) OPG (Rat) RBN-31K-1OC HBN51K1RANKL MBN-41K-1RANKL RBN-31K-1RANKL MBN-41K-1OPG RBN-31K-1OPGHuman CVD Panel 4(Cat. No. HCVD4MAG-67K)sE-Selectin Follistatin (FST) dPAPP-A Pecam-1 Pentraxin-3 (PTX3) Tissue Factor (TF) Thrombomodulin Tropinin T (TnT)Mouse CVD2(Cat. No. MCVD277BK) MB Format Coming Soon*Adiponectin Apo AI Apo E FibrinogenMouse Acute Phase Panel 1(Cat. No. MAP1MAG-76K)Lipocalin-2/NGAL Pentraxin-3 (PTX3) Serum Amyloid A-3 (SAA-3)* Coming Soon ** Discontinued non-magnetic bead format December 31, 2012nFor Research Use Only.Requires Sample Extraction Non-magnetic bead format9CV D / C A NCER / N EU RO SCIENCECardiovascular, continuedMouse Acute Phase Panel 2(Cat. No. MAP2MAG-76K)Adipsin a-1-Acid glycoprotein (AGP) a-2-Macroglobulin CRP Haptoglobin Serum Amyloid P Pentraxin-2Cancer BiomarkerHuman Circulating Cancer Biomarker Panel 1(Cat. No. HCCBP1MAG-58K)AFP CA125 CA15-3 CA19-9 CEA CYFRA21-1 FGF-2/FGF-basic HCG HE4 HGF IL-6 IL-8 Leptin MIF Osteopontin Prolactin PSA (free) PSA (total) SCF sFas sFasL TGFa TNFa TRAIL VEGFHuman Angiogenesis / Growth Factor(Cat. No. HAGP1MAG-12K)Angiopoietin-2 BMP-9 EGF Endoglin Endothelin-1 FGF-1/FGF-acidic FGF-2/FGF-basic Follistatin G-CSF HB-EGF HGF IL-8 Leptin PLGF VEGF-A VEGF-C VEGF-DRat CVD1(Cat. No. RCVD1-89K) MB Format Coming Soon*BNP IL-6 MCP-1 MPO PAI-1 TIMP-1 TNFa Troponin I Troponin T VEGF von Willebrand FactorMouse Angiogenesis / Growth Factor Panel 1MB Format Coming Soon*sALK-1 IL-6 IL-17A KC/CXCL1 Leptin MCP-1 MIP-1a PLGF-2 Prolactin SDF-1 TIMP-1 TNFa VEGF-A VEGF-C VEGF-D Amphiregulin Angiopoietin-2 Betacellulin sCD31/PECAM-1 EGF Endoglin Endothelin-1 sFASL FGF-2 Follistatin G-CSF HGF IL-1Human Circulating Cancer Biomarker Panel 2(Cat. No. HCCBP2MAG-58K)Antithrombin III Coagulation factor XIII Complement factor H (CFH) Extracellular matrix protein 1 (ECM1) Vitamin D binding protein VitronectinRat CVD2(Cat. No. RCVD2-89K) MB Format Coming Soon*sE-Selectin sICAM-1Human Circulating Cancer Biomarker Panel 3Cat. No. HCCBP3MAG-58K)Catalase Cathepsin D Ferritin Melanoma inhibitory activity (MIA)NeuroscienceHuman Neurodegenerative Disease Panel 1(Cat. No. HNDG1-36K) ** (Cat. No. HNDG1MAG-36K)a-2-Macroglobulin Complement C3 Apo AI Apo CIII Apo E Complement Factor H PrealbuminMyeloperoxidase Fibroblast activation (MPO) protein (FAP) Sex hormone binding globulin Galectin 3 (SHBG) IGFBP3Human Cancer / Metastasis Biomarker Panel 1(Cat. No. HCMBMAG-22K)DKK1 GDF15* Coming Soon For Research Use Only. ** Discontinued non-magnetic bead format December 31, 2012 Cannot be plexed together: 1) PSA (free) and PSA (total)nNEW!Periostin TRAP TWEAK YKL40NSE OPG Osteonectin (SPARC)Human Neurodegenerative Disease Panel 2(Cat. No. HNDG2-36K) ** (Cat. No. HNDG2MAG-36K)a-1-Antitrypsin Complement C4 CRP MIP-4 PEDF SAPNEW!Requires Sample Extraction Non-magnetic bead format10NEU RO SCIENCE / TOX I CI T YHuman Neurodegenerative Disease Panel 3(Cat. No. HNDG3-36K) ** (Cat. No. HNDG3MAG-36K)BDNF Cathepsin D MPO PAI-1 (total) PDGF-AA PDGF-AB/BB RANTES sICAM-1 sNCAM sVCAM-1Rat / Mouse NeuropeptideMB Format Coming Soon*a-MSH -Endorphin Neurotensin Orexin A Oxytocin Substance PnRat Kidney Toxicity Panel 2(Cat. No. RKTX2MAG-37K)AGP Albumin -2-Microglobulin Cystatin C EGF Lipocalin-2/NGALToxicityRat Kidney Toxicity Panel 1(Cat. No. RKTX1-37K)Clusterin KIM-1 OsteopontinHuman Kidney Toxicity Panel 1Serum samples (Cat. No. HKTX1MAG-38K)KIM-1 Osteopontin Renin TFF-3Human Neurodegenerative Disease Panel 4CSF Samples (Cat. No. HNDG4MAG-36K)A1-40 A1-42 GDNF S100B sRAGERat Kidney Toxicity Panel 2(Cat. No. RKTX2-37K)Albumin -2-Microglobulin Cystatin CHuman Kidney Toxicity Panel 2Serum samples (Cat. No. HKTX2MAG-38K)-2-Microglobulin Clusterin Cystatin CHuman Neurological Disorders Panel 1CSF Samples (Cat. No. HND1MAG-39K)a-Synuclein NGF NSE PARK5/UCHL1 PARK7/DJ1 Tau (Thr231) Tau (total)Single Plex Toxicity Kitsa-2-Microglobulin (Rat)*Canine Kidney Toxicity Panel 1Urine Samples (Cat. No. CKTX1MAG-97K)Clusterin Cystatin C KIM-1NEW!Human Kidney Toxicity Panel 3Urine samples (Cat. No. HKTX3MAG-38K)KIM-1 Renin TFF-3Human Neurological Disorders Panel 2(Cat. No. HND2MAG-39K)AGP CP HP Serum Amyloid PCanine Kidney Toxicity Panel 2MB Format Coming Soon*Albumin OsteopontinHuman Kidney Toxicity Panel 4Urine samples (Cat. No. HKTX4MAG-38K)Albumin -2-Microglobulin Clusterin Cystatin C OsteopontinHuman Neurological Disorders Panel 3MB Format Coming Soon*a1-antichymotrypsin Neurotrophin-4 (NT-4) Contactin-1 Osteopontin (OPN) Contactin-2 SOD1 Neurofilament L (NF-L)Rat Vascular Injury Panel 1MB Format Coming Soon*Caveolin-1 CINC-1/GRO CTGF MCP-1 PAI-1 TIMP-1 sVCAM-1 VEGF von Willebrand FactorRat Kidney Toxicity Panel 1(Cat. No. RKTX1MAG-37K)Calbindin KIM-1 Osteopontin TIMP-1 VEGF Clusterin GSTa IP-10Human Neuropeptide(Cat. No. HNPMAG-35K)a-MSH -Endorphin Cortisol MelatoninnNeurotensin Orexin A Oxytocin Substance PFor Research Use Only.11I NF L A M M ATI O N / I M M U NO LO GYInflammation / ImmunologyHuman Cytokine / Chemokine Panel I(Cat. No. MPXHCYTO-60K) (Cat. No. HCYTOMAG-60K) (Cat. No. HCYTMAG-60K-PX29) Cat. No. HCYTMAG-60K-PX30 (Cat. No. HCYTMAG-60K-PX38) (Cat. No. HCYTMAG-60K-PX41)EGF Eotaxin FGF-2 Flt3 ligand Fractalkine G-CSF GM-CSF GRO IFNa2 IFN IL-1a IL-1 IL-1ra IL-2 IL-3 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 IL-10 IL-12 (p40) IL-12 (p70) IL-13 IL-15 IL-17A IP-10 MCP-1/CCL2 MCP-3/CCL7 MDC/CCL22 MIP-1a MIP-1 PDGF-AA PDGF-AB/BB RANTES sCD40L TGFa TNFa TNF VEGF Human Cytokine / Chemokine Panel II(Cat. No. MPXHCYP2-62K) ** (Cat. No. HCYP2MAG-62K) (Cat. No. HCP2MAG-62K-PX23)6Ckine/CCL21 BCA-1/CXCL13 CTACK/CCL27 ENA-78/CXCL5 Eotaxin-2/CCL24/MPIF-2 Eotaxin-3/CCL26 IL-16 IL-20 IL-21 IL-23 IL-28A IL-33/NF-HEV (mature) I-309/CCL1 LIF MCP-2 MCP-4 MIP-1d (MIP-5/CCL15) SCF SDF-1a+/CXCL12 TARC/CCL17 TPO TRAIL/TNFSF10 TSLPHuman High Sensitivity Cytokine / Chemokine(Cat. No. HSCYTO-60SK) (Cat. No. HSCYTMAG-60SK) (Cat. No. HSCYMAG60SPMX13)GM-CSF IL-1 IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-10 IL-12 (p70) IL-13 IFN TNFa29 30 38 412313Human Soluble Cytokine Receptor(Cat. No. HSCR-32K) MB Format Coming Soon*sCD30 sEGFR sgp130 sIL-1RI sIL-1RII sIL-2Ra sIL-4R sIL-6R sRAGE sTNF RI sTNF RII sVEGF R1 sVEGF R2 sVEGF R3Human Th17(Cat. No. HTH17MAG-14K) (Cat. No. HT17MG-14K-PX25)GM-CSF IFN IL-1 IL-17F IL-21 IL-22 IL-23 IL-27 IL-28A IL-31 IL-33 MIP-3a TNFa TNFNEW!25IL-17E/IL-25Human Cytokine / Chemokine Panel III(Cat. No. MPXHCYP3-63K) (Cat. No. HCYP3MAG-63K)HCC-1/CCL14a IL-11 IL-29/IFN2 I-TAC/CXCL11 LIX/CXCL6/GCP-2 Lymphotactin M-CSF MIG/CXCL9 MIP-3a/CCL20 MIP-3/CCL19 NAP-2/CXCL7**IL-2 IL-4 IL-5 IL-6 IL-9 IL-10 IL-12 (p70) IL-13 IL-15 IL-17A* Coming Soon ** Discontinued non-magnetic bead format December 31, 2012 For Research Use Only. Cannot be plexed together: 1) PDGF-AA. PDGF-AB/BB and RANTES 2) HCC-1/CCL14a and NAP-2/CXCL7 Analytes In HCYTMAG-60K-PX30 Non-magnetic bead format Analytes In MCYTOMAG-70K-PMX12I NF L A M M ATIO N / I M M U NO LO GYHuman CD8+ T CellMB Format Coming Soon*sCD137 sFas sFasL GM-CSF Granzyme A Granzyme B IFN IL-2 IL-4 IL-5 IL-6 IL-10 IL-13 MIP-1a MIP-1 Perforin TNFaNon-Human Primate Cytokine/Chemokine(Cat. No. MPXPRCYTO-40K) (Cat. No. PRCYTOMAG-40K) (Cat. No. PCYTMG-40K-PX23)G-CSF GM-CSF IL-1 IL-1ra IL-2 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12/23 (p40) IL-13 IL-15 IL-17A IL-18 IFN MCP-1/CCL2/MCAF MIP-1a MIP-1 sCD40L TGFa TNFa VEGFMouse Cytokine / Chemokine Panel III(Cat. No. MCYP3MAG-74K)IL-2023IL-33 MDC TIMP-1IL-23 IL-27Mouse Soluble Cytokine Receptor(Cat. No. MSCR-42K) ** (Cat. No. MSCRMAG-42K)sCD30 sgp130 sIL-1RI sIL-1RII sIL-2Ra sIL-4R sIL-6R sRAGE sTNF RI sTNF RII sVEGF R1 sVEGF R2 sVEGF R3NEW!Human MMP 1(Cat. No. HMMP1-55K) MB Format Coming Soon*MMP-3 MMP-12 MMP-13Human MMP 2(Cat. No. HMMP2-55K) (Cat. No. HMMP2MAG-55K)MMP-1 MMP-2 MMP-7 MMP-9 MMP-10Mouse Cytokine / Chemokine Panel I(Cat. No. MPXMCYTO-70K) (Cat. No. MCYTOMAG-70K) (Cat. No. MCYTOMAG-70K-PMX) 25 (Cat. No. MCYTMAG-70K-PX32) 32Eotaxin G-CSF GM-CSF IFN IL-1a IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-7 IL-9 IL-10 IL-12 (p40) IL-12 (p70) IL-13 IL-15 IL-17A IP-10 KC LIF LIX MCP-1/CCL2 M-CSF MIG MIP-1a MIP-1 MIP-2 RANTES TNFa Mouse Th17(Cat. No. MTH17MAG-47K) (Cat. No. MT17MAG47K-PX25)GM-CSF IFN IL-1 IL-2 IL-4 IL-5 IL-6 IL-10 IL-12 (p70) IL-13 IL-15 IL-17A IL-17E/IL-25 IL-17F IL-21 IL-22 IL-23 IL-27 IL-28A IL-28B IL-31 IL-33 MIP-3a TNFa TNF25Human TIMP 1Serum samples (Cat. No. HTMP1MAG-54K)TIMP-1 TIMP-2Human TIMP 2Cell culture samples (Cat. No. HTMP2MAG-54K)TIMP-1 TIMP-2 TIMP-3 TIMP-4Mouse CD8+ T Cell(Cat. No. MCD8MAG-48K) (Cat. No. MCD8MAG48K-PX15)sCD137 sFas sFasL GM-CSF Granzyme B IFN IL-2 IL-4 IL-5 IL-6 IL-10 IL-13 MIP-1 RANTES TNFaFor Research Use Only.15Mouse Cytokine / Chemokine Panel II(Cat. No. MCYP2MAG-73K)EPO Exodus-2 Fractalkine IL-16 IL-21 IL-22 IL-17E/IL-25 IL-28B MCP-5 MIP-3a MIP-3 TARC13I N F L AMMAT I O N / I M M U NO LO GY / I M M U NE R ESPO NSEInflammation / Immunology, continuedMouse MMP Panel 1 Serum/plasma SamplesMB Format Coming Soon*MMP-2 MMP-3 MMP-8Immune ResponseNEW! NEW!Porcine Cytokine / Chemokine(Cat. No. PCYTMAG-23K) (Cat. No. PCYTMG-23K-13PX)GM-CSF IFN IL-1a IL-1ra IL-1 IL-2 IL-4 IL-6 IL-8 IL-10 IL-12 IL-18 TNFa13Human Immunoglobulin Isotyping(Cat. No. HGAMMAG-301K)IgA IgG1 IgG2 IgG3 IgG4 IgMMouse MMP Panel 2 Serum/plasma SamplesMB Format Coming Soon*MMP-9 MMP-12Mouse Immunoglobulin Isotyping(Cat. No. MGAMMAG-300K)IgA IgG1 IgG2a IgG2b IgG3 IgMMouse MMP Panel 3 Cell culture samplesMB Format Coming Soon*MMP-2 MMP-3 MMP-8 MMP-9 MMP-12Multi-species TGF - 1 plex(Cat. No. TGFB-64K-01) MB Format Coming Soon*TGF1Rat Immunoglobulin Isotyping(Cat. No. RGAMMAG-302K)IgG1 IgG2a IgG2b IgG2c IgA IgE IgMMulti-species TGF - 3 plex (Cat. No. TGFB-64K-03) MB Format Coming Soon*TGF127Rat Cytokine / Chemokine(Cat. No. RECYTMAG-65K) (Cat. No. RECYMAG65K27PMX)EGF Eotaxin Fractalkine G-CSF GM-CSF GRO-KC IFN IL-1a IL-1 IL-2 IL-4 IL-5 IL-6 IL-10 IL-12 (p70) IL-13 IL-17A IL-18 IP-10 Leptin LIX MCP-1 MIP-1a MIP-2 RANTES TNFa VEGFTGF2 TGF3Single Plex IgEIgE (Human) IgE (Mouse) HGMAMAG-303E MIGEMAG-300K-01Human Sepsis Panel 1(Cat. No. HSP1MAG-63K)MIF PAI-1 (total) sFas sFasL sICAM-1 sVCAM-1Human Sepsis Panel 2(Cat. No. HSP2MAG-63K)Granzyme B HSP70 IL-1a IL-8 MIP-1a MIP-1 MMP-8Canine Cytokine / Chemokine(Cat. No. CCYTOMAG-90K) (Cat. No. CCYTMG-90K-PX13)GM-CSF IFN IL-2 IL-6 IL-7 IL-8 IL-1013Human Sepsis Panel 3(Cat. No. HSP3MAG-63K)Lactotransferrin (LTF) Lipocalin-1 Neutrophil Elastase-2 (ELA2) Resistin Thrombospondin-1 (TSP-1)IL-15 IL-18 IP-10 KC-like MCP-1/CCL2/MCAF TNFaHuman Skin(Cat. No. SKIN-50K) MB Format Coming Soon*For Research Use Only.Cortisol Fibronectin* Coming SoonKeratin-6 Keratin-1,10 LPSPanel Premix Only Non-magnetic bead formatHuman Serum Albumin (HSA) Involucrin14See our website for Single Plex Kit catalogue numbers.Cell Signaling & Phosphoprotein DetectionNew Challenges, Faster AnswersMultiplexing, using the Luminex xMAP platform, provides faster answers to cell signaling questions compared to traditional Western blots, mass spectrometry analysis, and radioactive phosphorylation assays that require large amounts of sample. Now available are three MILLIPLEX map cell signaling portfolios based on the Luminex xMAP platform. Stem Cell AssaysOur MILLIPLEX map Stem Cell biomarker assays enable you to characterize your ES cells, iPS cells, or even your cancer cells using the Luminex xMAP platform. Our upcoming panels are of interest to many areas of research, including development and oncology.MILLIPLEX map Cellular Metabolism Assays MILLIPLEX map Stem Cell Assays MILLIPLEX map Cell Signaling AssaysMILLIPLEX map Cell Signaling AssaysOur cell signaling kits and MAPmates offer you the ability to: Measure multiple total or phosphorylated proteins along a signaling pathway, in a single sample Simultaneously measure sites in multiple pathways Conduct all necessary measurements using minimal sample volume Choose from analytically validated kits or design your custom assay with our MAPmatesMIL L IPL EX m a p CEL L SIGN AL INGCellular Metabolism AssaysOur MILLIPLEX map Cellular Metabolism Panels will enable you to: Measure analytes within the panels in small sample sizes of cell lysate or tissue extract Examine intracellular pathways regulating cellular metabolism and energy production Facilitate research areas such as mitochondrial dysfunction and toxicity, metabolic disorders, neurological disorders, cancer and agingFor Research Use ELLU L A R M ETA BO LISM / S TEM CELLCellular Metabolism AssaysMulti-species Pyruvate Dehydrogenase (PDH) Complex (Cat. No. PDHMAG-13K)Analyte PDH PDH PDH PDH Total 3 3 (Ser232) 3 (Ser293) 3 (Ser300) PhosphorylatedHuman Drug Metabolism(Cat. No. HDMMAG-19K)ALDH4A1 CES1 EPHX1 MAO-A MAO-BHuman Fatty Acid Oxidation Panel 1(Cat. No. HFA01MAG-11K)Acetyl-CoA acyltransferase 2 (ACAA2) Peroxisomal bifunctional enzyme (LPBE/ECHD) Short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) Mitochondrial trifunctional protein (TFP)Stem Cell AssaysHuman Stem Cell Pluripotency Panel 1 (Cat. No. 48-617MAG)c-Myc Nanog Oct 3/4 Sox2NEW!Human Fatty Acid Oxidation Panel 2(Cat. No. HFA02MAG-11K)Carnitine palmitoyltransferase 2 (CPT2) 2,4-dienoyl-CoA reductase (DECR1) Electron transfer flavoprotein, mitochondrial (ETF) Medium-chain acyl-CoA dehydrogenase (MCAD) Peroxisomal multifunctional enzyme 2 (MFE2)Human Stem Cell Pluripotency Panel 2 MB Format Coming Soon*E-cadherin EpCam KLF4 LIN-28 SSEA1 TRA-1-60 TRA-1-80Human Oxidative Phosphorylation MIL L IPL EX m a p CEL L SIGN AL ING(Cat. No. H0XPSMAG-16K)Complex I (NADH-Ubiquinone Oxidoreductase) Complex II (Succinate Ubiquinone Oxidoreductase) Complex III (Ubiquinone Cytochrome C Oxidoreductase) Complex IV (Cytochrome C Oxidase) Complex V (ATP Synthase) NNT (Nicotinamide Nucleotide Transhydrogenase)Cell SignalingAkt / mTOR 11 Plex(Cat. No. 48-611MAG)Analyte Akt GSK3a GSK3 IGF1R IR IRS1 mTOR p70 S6 Kinase PTEN RPS6 TSC2TotalPhosphorylated 3 (Ser473) 3 (Ser21) 3 (Ser9) 3 (Tyr1135/1136) 3 (Tyr1162/1163) 3 (Ser312) 3 (Ser2448) 3 (Thr412) 3 (Ser380) 3 (Ser235/236) 3 (Ser939)Rat/Mouse Oxidative Phosphorylation (Cat. No. RM0XPSMAG-17K)Complex I (NADH-Ubiquinone Oxidoreductase) Complex III (Ubiquinone Cytochrome C Oxidoreductase) Complex V (ATP Synthase)Human Oxidative Stress (Cat. No. H0XSTMAG-18K)Catalase PRX2 (PRDX2) SOD1For Research Use Only.SOD2 TRX116See our website for species cross-reactivity.C ELL S IG NA LINGTotal Akt / mTOR 11 Plex(Cat. No. 48-612MAG)Analyte Akt GSK3a GSK3 IGF1R IR IRS1 mTOR p70S6 Kinase PTEN RPS6 TSC2Early Apoptosis 7 Plex(Cat. No. 48-669MAG)NEW!Total 3 3 3 3 3 3 3 3 3 3 3PhosphorylatedAnalyte Akt BAD Bcl-2 Active Caspase 8 Active Caspase 9 JNK p53TotalPhosphorylated 3 (Ser473) 3 (Ser112) 3 (Ser70)3 3 3 (Thr183/Tyr185) 3 (Ser46)Human Late Apoptosis 3 Plex(Cat. No. 48-670) ** (Cat. No. 48-670MAG) Analyte Active Caspase 3 Cleaved PARP GAPDH Total 3 3 3 PhosphorylatedNEW!Human Angiogenesis RTK 10 Plex(Cat. No. 48-674MAG)Analyte c-Kit Flt3 M-CSFR PDGFRa PDGFR Tie1 Tie2 VEGF R1 VEGF R2 VEGF R3TotalPhosphorylated 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr)Human EGFR Profiler 8 Plex(Cat. No. 48-613MAG)Analyte EGFR EGFR EGFR EGFR EGFR EGFR EGFR EGFRTotal 3Phosphorylated 3 (Thr654) 3 (Thr669) 3 (Tyr845) 3 (Tyr1045) 3 (Ser1047) 3 (Tyr1068) 3 (Tyr1086)Human Total Angiogenesis RTK 10 Plex(Cat. No. 48-673MAG)Analyte c-Kit Flt3 M-CSFR PDGFRa PDGFR Tie1 Tie2 VEGF R1 VEGF R2 VEGF R3Total 3 3 3 3 3 3 3 3 3 3PhosphorylatedHuman Heat Shock Protein 5 Plex(Cat. No. 48-615MAG)Analyte HSP27 Phospho-HSP27 HSP60 HSP70 HSP90a 3 3 3Total 3Phosphorylated 3 (Ser78/Ser82)For Research Use Only.* Coming SoonPanel Only Premix** Discontinued non-magnetic bead format December 31, 2012 Non-magnetic bead format17CELL SIG NA LINGCell Signaling, continuedMAPK / SAPK 10 Plex(Cat. No. 48-660) ** (Cat. No. 48-660MAG) Analyte ATF2 ErK/MAPK 1/2 HSP27 JNK c-Jun MEK1 MSK1 p38 (SAPK2A/B) p53 STAT1 Total Phosphorylated 3 (Thr71) 3 (Thr185/Tyr187) 3 (Ser78) 3 (Thr183/Tyr185) 3 (Ser73) 3 (Ser222) 3 (Ser212) 3 (Thr180/Tyr182) 3 (Ser15) 3 (Tyr707)NEW!STAT 5 Plex(Cat. No. 48-610) ** (Cat. No. 48-610MAG) Analyte STAT1 STAT2 STAT3 STAT5A/B STAT6 Total Phosphorylated 3 (Tyr701) 3 (Tyr690) 3 (Tyr705) 3 (Tyr694/699) 3 (Tyr641)Src Family Kinase 8 Plex(Cat. No. 48-650)Analyte Blk Fgr Fyn Hck Lck Lyn Src Yes**TotalPhosphorylated 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr)Human Mitogenesis RTK 7 Plex(Cat. No. 48-672MAG)Analyte cMet/HGFR EGFR ErbB2/HER2 ErbB3 ErbB4 IGF1R IRTotalPhosphorylated 3 pan Tyr 3 pan Tyr 3 pan Tyr 3 pan Tyr 3 pan Tyr 3 pan Tyr 3 pan TyrSrc Family Kinase Active Site 8 Plex(Cat. No. 48-650MAG)Analyte Blk Fgr Fyn Hck Lck Src YesNEW!TotalPhosphorylated 3 (Tyr389) 3 (Tyr412) 3 (Tyr420) 3 (Tyr411) 3 (Tyr394) 3 (Tyr419) 3 (Tyr421)Human Total Mitogenesis RTK 7 Plex(Cat. No. 48-671MAG)Analyte cMet/HGFR EGFR ErbB2/HER2 ErbB3 ErbB4 IGF1R IRTotal 3 3 3 3 3 3 3PhosphorylatedT-Cell Receptor 7 Plex(Cat. No. 48-690) ** (Cat. No. 48-690MAG)Analyte CD3e CREB Phosphorylated 3 (Ser473) 3 (Ser133) 3 (Thr185/Tyr187) 3 (Ser536) 3 (Thr183/Tyr185) 3 (Thr180/Tyr182) 3 (Thr412) 3 (Ser727) 3 (Tyr694/699) Erk/MAPK 1/2 LAT Lck Syk ZAP-70NEW!TotalPhosphorylated 3 (pan Tyr) 3 (Ser133) 3 (Thr185/Tyr187) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr) 3 (pan Tyr)Multi-Pathway 9 Plex(Cat. No. 48-680MAG)Analyte Akt CREB Erk/MAPK 1/2For Research Use Only.TotalNFkB JNK p38 p70 S6 Kinase STAT3 STAT5A/B18See our website for cross reactivity.CELL SIG NA LINGTGF 6 Plex(Cat. No. 48-614MAG)Analyte Akt Erk SMAD2 SMAD3 SMAD4 TGFRII 3 3LysatesTotal Phosphorylated 3 (Ser473) 3 (Thr185/Tyr187) 3 (Ser465/467) 3 (Ser423/425) Hek293: 10% Serum HEK293: IGF-1 HeLa: HGF HeLa: IFNa HeLa: LambdaphosphataseNEW!Analyte A431: EGF A549:camptothecin Daudi: IL-4Cat. No. Analyte 47-210 47-218 47-217 47-233 47-228 47-222 47-226 47-229 47-223 47-212 47-230 47-205 47-211 47-227 HEPG2: TGF2 HFF-1: 10% Serum HUVEC: 10% Serum Jurkat: anisomycin Jurkat: paclitaxel Jurkat: unstim Jurkat:H2O2 Kasumi-3:SCF MCF7:IGF-1 NIG3T3: PDGF-AB NIH3T3: anisomycin NIH3T3: unstim Ramos: PVD THP-1: 10% SerumCat. No. 47-235 47-237 47-238 47-207 47-220 47-206 47-208 47-214 47-216 47-213 47-219 47-221 47-224 47-236Akt 2 Plex(Cat. No. 48-618MAG) MB Format Coming Soon*Analyte Akt Akt Total 3 3 (Ser473) PhosphorylatedHeLa: PVD HeLa: TNFa HeLa: TNFa+CalA HeLa: unstim HeLa:HS/Ars HepG2: InsulinErk / MAPK 1/2 2 Plex(Cat. No. 48-619MAG) MB Format Coming Soon*Analyte Erk Erk Total 3 3 (Thr185/Tyr187) PhosphorylatedNEW!For Research Use Only.* Coming SoonPanel Only Premix** Discontinued non-magnetic bead format December 31, 2012 Non-magnetic bead format19M A Pma tes MAPmates Cell Signaling Single-plex KitsThe following MAPmates should not be plexed together: MAPmates that require a different assay buffer Phosphospecific and total MAPmate pairs, e.g. total GSK3 and GSK3 (Ser 9) Pan Tyr and site-specific MAPmates, e.g. Phospho-EGF Receptor and HSP27 (Ser78) More than 1 phospho-MAPmate for a single target (Akt, STAT3, p53, Src, Rb) GAPDH and -Tubulin can not be plexed with kits or MAPmates containing panTyrAnalyte p53 p53 p70 S6 Kinase Cleaved PARP PRAS40 PTEN Rb Rb Rb Src Src STAT1 STAT2 Analyte GAPDH (Human) Akt/PKB (assay buffer 1) Akt/PKB (assay buffer 1) Akt/PKB (assay buffer 2) ATF2 BAD Active Caspase 3 CREB EGF Receptor Erk/MAPK 1/2 GSK3 H2A.X HIF-1a HSP27 IGF1 Receptor IkBa Insulin Receptor (IR) IRS1 JNK/SAPK1 c-Jun c-Kit Lck Lck Lyn c-Met/HGFR MEK1 46-707 46-650 46-669 46-685 46-701 46-621 46-612 (Thr180/Tyr182) 46-610 46-620 46-665 46-608 46-646 46-644 46-687 46-628 46-618 (Ser78) 46-607 (Pan Tyr) 46-647 (Ser32) 46-643 (Tyr1162/1163) 46-688 (Pan Tyr) 46-627 (Thr183/Tyr185) 46-613 (Ser73) 46-622 (Pan Tyr) 46-619 (Pan Tyr) 46-616 (Tyr394) 46-712 (Tyr397) 46-708 (Pan Tyr) 46-651 (Ser222) 46-670 (Ser2448) 48-686 (Ser536) 46-702 46-695 46-604 46-632 46-606 46-609 46-689 (Ser133) 46-631 (Pan Tyr) 46-603 (Thr185/Tyr187) 46-602 (Ser9) 46-690 (Ser139) 46-692 46-675 Total 46-667 46-605 (Ser473) 46-601 (Thr308) 46-645 (Ser473) 46-677 (Thr71) 46-658 (Ser112) 46-694 Phosphorylated STAT3 STAT3 STAT5A/B ZAP-70 46-625 46-654 46-709 46-630 46-656 46-680 46-678 46-703 (Thr246) 46-681 (Ser380) 46-679 (Thr252) 46-704 (Ser811) 46-706 (Thr826) 46-705 (Tyr419) 46-710 (Tyr530) 46-711 (Tyr701) 46-655 (Tyr690) 46-635 (Tyr705) 46-623 (Ser727) 46-624 (Tyr694/699) 46-641 (Pan Tyr) 46-661 Total 46-662 Phosphorylated (Ser15) 46-663 (Ser46) 46-664 (Thr412) 46-629Buffer & Detection Kit(Cat. No. 48-602)Required to run all MAPmate assays.Magnetic Bead FormatAnalyte GAPDH (Human) -Tubulin (Human/Rat/ Mouse) Akt/PKB (assay buffer 2) Active Caspase 3 CREB EGF Receptor Erk/MAPK 1/2 GSK3b IkBa JNK/SAPK1 c-Jun c-Kit MEK1 c-Met/HGFR mTOR p21 p38 (SAPK2A/B) p70S6K RPS6 STAT1 STAT3 STAT3 STAT5A/B Tie2 VEGFR2* Coming SoonTotal 46-667MAG 46-713MAG * *Phosphorylated(Ser473) * ** * * * * * * * * * * * * * *(Pan Tyr) * (Thr185/Tyr187) * (Ser9) * (Ser32) * (Thr183/Tyr185) * (Ser73) * (Pan Tyr) * (Ser222) * (Pan Tyr) * (Ser2448) * (Thr180/Tyr182) * (Thr412) * (Ser235/236) * (Tyr701) * (Tyr705) * (Ser272) * (Tyr694/699) *For Research Use Only.mTOR NFkB p21 p38 (SAPK2A/B)* *(Pan Tyr) * (Pan Tyr) *20Luminex xMAP TechnologyLU M INEX TECH NO LO GYAs a Luminex partner, EMD Millipore is a distributor of Luminex instruments, accessories and software. We were there at the beginning to help validate Luminex as a standard of multiplexing, and our ongoing dedication and experience in this technology enable you to gain more information faster, without compromising reliability. Visit our website at for more information on the following technologies:MAGPIX System(Cat. No. 40-072 - MAGPIX) (Cat. No. 40-073 - MAGPIX with MILLIPLEX Analyst Software)Luminex 200 System(Cat No. 40-012- MILLIPLEX Analyzer) (Cat No. 40-013 - MILLIPLEX Analyzer with MILLIPLEX Analyst Software)MILLIPLEX Analyzer, the Luminex 200 System, is a compact lab analysis system that integrates lasers, optics, fluidics, a controller, advanced digital signal processing, an XY Platform, the newest version analysis software, and a PC with monitor. Specifically designed to enhance the use of xMAP technology, this system enables simultaneous assays of up to 100 analytes per well of a microtiter plate. Key features include: flexible data analysis package, user friendly functions, flexible assay design features, bar code reader for enhanced efficiency and multiple formats for generating data reports.Combined with our MILLIPLEX MAP magnetic bead-based multi-analyte panels, analysis software and technical support, the new Luminex MAGPIX system provides a complete solution for rapid, accurate biomarker quantitation in a variety of sample matrices. This affordable system can perform up to 50 tests simultaneously in a single reaction volume, greatly reducing sample input, reagents and labor while improving productivity. The MAGPIX system features an innovative design based on CCD imaging technology that enables for a more compact, robust system. In addition, it is easy to operate and maintain with streamlined start-up and shutdown protocols and minimal maintenance requirements.Luminex FLEXMAP 3D System(Cat. No. 40-014 - FLEXMAP 3D) (Cat. No. 40-022 - FLEXMAP 3D with MILLIPLEX Analyst Software)The FLEXMAP 3D system combines differentially dyed fluorescent microsphere sets with an innovative instrument design that can accommodate measuring the concentrations of up to 500 unique analytes within a single sample rapidly and precisely. Featuressuch as automated probe height adjustment, simplified routine maintenance operations and an intuitive software interfacemake FLEXMAP 3D a flexible and easy-to-use multiplexing system.For Research Use Only.IN S TRUM ENT S & SOFT WAR E21M I LLI PLEX A NA LYS T SO F T WA REMILLIPLEX Analyst SoftwareMILLIPLEX Analyst 5.1(Cat. No. 40-082 MILLIPLEX Analyst 5.1 - upgrade (for 3.5 users)) (Cat. No. 40-086 MILLIPLEX Analyst 5.1 1 seat license) (Cat. No. 40-087 MILLIPLEX Analyst 5.1 5 seat license) (Cat. No. 40-088 MILLIPLEX Analyst 5.1 database, 1 seat license) (Cat. No. 40-089 MILLIPLEX Analyst 5.1 database, 5 seat license)A new level of data analysis to help you do your best work!EMD Millipore combines the streamlined data acquisition power of xPONENT software with sophisticated analysis capabilities of the new MILLIPLEX Analyst 5.1, enabling you to manage, track and analyze your multiplex assays fast and efficiently. Data acquisition and analysis integrates seamlessly with all Luminex instruments, including MAGPIX, Luminex 200 and FLEXMAP 3D systems. MILLIPLEX Analyst 5.1 is available as one- and five-seat licenses, enabling complete flexibility for small, medium and large laboratories. You can easily create reports in multiple formats for enhanced presentations.INS TRUM ENT S & S OFT WAREMILLIPLEX Analyst 5.1 software offers simple integration with Luminex xPONENT System: Seamless importing of CSV or Excel files User-friendly plate setup for flexibility and efficiency Calculate large data sets in seconds Superior algorithms yield better data at the low and high ends of the standard curveFor Research Use Only. Flexible report formats and enhanced presentation ILLIPLEX A NA LYS T SO F T WA RENew features of MILLIPLEX Analyst 5.1 software: Complete with CD and Dongle (USB/Thumb drive) for quick and easy download Auto-detect data features for standards, quality controls and samples Increased high-end standard value capabilities The best curve fit possible (using gold standard algorithms) Multiple Quality Control values (up to 5) Curve Potency feature (comparing two standard curves) Reports values for CHI and CVs Complete quantitative and qualitative analysis for improved flexibility 21CFR part 11 available option Automatic download on 32 or 64 bit computers Optional database package available late 2012MILLIPLEX Analyst 5.1 PLUS Easy Integration: Export compatiblePDF and Microsoft Excel formats Compatible with all Luminex 1.7 file formats Import data from Microsoft Excel, Bio-Plex (.txt), Miraibio (.txt), and other Luminex software programsBetter Curve Fit (High R2)Analyte GM-CSF IFN IL-1B IL-2 IL-4 IL-5 Il-6 TNFa CHI 6.80% 6.31% 10.04% 7.66% 1.23% 11.67% 16.48% 8.71% CV 1.15% 0.84% 1.23% 2.84% 0.20% 1.18% 1.71% 1.01% R2 0.999 0.999 0.998 0.999 1 0.998 0.996 0.999 MinDC 0.42 0.35 0.41 0.32 0.32 0.42 0.42 0.36 MaxDC 5431 6189 8441 7796 8711 5417 7494 7207Among many improved features available with MILLIPLEX Analyst 5.1 software is 5PL weighted curve fit, enabling superior curve fit (R2 above 0.995) at both extremes of typical standard curves.For Research Use Only.23WA SH ING SO LU TIO NSMagnetic Bead Kit Washing SolutionsNEW! ELx405TSRSML and Elx405LSRML Microplate Washer For 96-Well Biomagnetic Separation(Cat. No. 40-094 BioTek 96-well Magnetic Washer) (Cat. No. 40-095 BioTek 96-well Magnetic/Vacuum Filtration Washer) (Cat. No. 40-096 BioTek 96-well Magnetic Washer with Touch Screen and Ultrasound) (Cat. No. 40-097 BioTek 96-well Magnetic /Vacuum Filtration Washer with Touch Screen and Ultrasound)In partnership with BioTek we now offer the newest ELx405 enhancement: full plate biomagnetic separation, washing and vacuum filtration system for magnetic bead assays. Both systems offer magnetic and filtration washing optionswith the TS model now offering touch screen and ultra-sound capabilities.BioTek Washer Advantages: Touch screen, high resolution LED backlit user interface screen Magnetic bead washingLuminex xMAP approved Fast and efficient vacuum filtration Optional software package Built-in Ultrasonic Advantage cleanerHandheld Magnetic Separator Block for 96-Well Flat Bottom Plates or 96-Well Conical Well Plates(Cat. No. 40-285)The Handheld Magnetic Separator Block offers a low cost option for biomagnetic separation. Magnets are positioned around the bottom of the well to pull the beads to the side of the well. The top magnetic frame is white polycarbonate, with a corrosion resistant steel plate underneath, all mounted to a polypropyleneFor Research Use Only.base. An adjustable clip system holds a wide variety of microplates to the separator block, and an O-Ring on the base plate facilitates gripping.24Versatility in a Complete PackageMILLIPLEX map Magnetic Bead-based Immunoassay KitsAs your research needs broaden, were growing with you.As we continue to expand our magnetic bead-based multiplexing portfolio, we need to do some housekeeping to make room for innovative and unique panels targeting new species in emerging areas of research. Consequently, we will be discontinuing some of our non-magnetic bead kits by December 31, 2012*. Below is a list of soon-to-be discontinued non-magnetic bead panels and the corresponding replacement magnetic bead panels.Discontinued NonMagnetic Catalogue No. 48-650 48-670 48-610 48-690 48-660 MSCR-42K HNDG1-36K HNDG2-36K HNDG3-36K MPXHCYP2-63K MPXHCYP2PMX23 MPXHCYP3-68K MPXHCYP3-PMX9 MPXHCYP3-PMX11 HBN1A-51K HBN1B-51KKit Description Non-Magnetic Bead Panel Src Family Kinase - 8 Plex Human Late Apoptosis - 3 Plex STAT - 5 Plex T-Cell Receptor - 7 Plex MAPK/SAPK - 10 Plex Mouse Soluble Cytokine Receptor Human Neurodegenerative Disease Panel 1 Human Neurodegenerative Disease Panel 2 Human Neurodegenerative Disease Panel 3 Human Cytokine Panel 2 Human Cytokine Panel 2 Human Cytokine Panel 3 Human Cytokine Panel 3 Human Cytokine Panel 3 Human Bone Panel 1A Human Bone Panel 1BReplacement Magnetic Bead Catalogue No. 48-650MAG 48-670MAG 48-610MAG 48-690MAG 48-660MAG MSCRMAG-42K HNDG1MAG-36K HNDG2MAG-36K HNDG3MAG-36K HCYP2MAG-62K HCP2MAG-62K-PX23 HCYP3MAG-63K HCP3MAG-63K-PX11 HBNMAG-51K HBNMAG-51KKit Description Magnetic Bead Panel Src Family Kinase - 8 Plex Human Late Apoptosis - 3 Plex STAT - 5 Plex T-Cell Receptor - 7 Plex MAPK/SAPK - 10 Plex Mouse Soluble Cytokine Receptor Human Neurodegenerative Disease Magnetic Bead Panel 1 Human Neurodegenerative Disease Magnetic Bead Panel 2 Human Neurodegenerative Disease Magnetic Bead Panel 3 Human Cytokine Panel II Human Cytokine Panel II, 23 Premix Human Cytokine Panel III Human Cytokine Panel III, 11 Premix Human Bone Panel Human Bone PanelPANEL UPDATES* Availability of inventory is subject to depletion of existing inventory. For more information, please contact your local account manager at: /offices25Drug Discovery & Development ServicesOur target profiling and contract research services help you prioritize potential drug candidates and screen protein and nucleic acid biomarkers from research through development.Biomarker AnalysisWith over 25 years of experience and industry leadership in developing and performing immunoassays on human and animal specimens, we offer proven bioanalytical services for biomarkersfrom research to clinical trials and beyond. Learn more at Place an Order or Receive Technical AssistanceIn the U.S. and Canada, call toll-free 1-800-645-5476 For other countries across Europe and the world, please visit: For Technical Service, please visit: Connected!Join EMD Millipore bioscience on your favorite social media outlet for the latest updates, news, products, innovations and contests! Detect CELISAs, MILLIPLEX, MultiScreen and OxyELISA are registered trademarks of Merck KGaA, Darmstadt, Germany. EMD Millipore, the M mark, ChemiKine, MAPmates, and SignalProfiler are trademarks of Merck KGaA, Darmstadt, Germany. FLEXMAP 3D, Luminex, MAGPIX, xPONENT, and xMAP are registered trademarks of Luminex Corporation. Luminex 200 is a trademark of Luminex Corporation. Biotek is a registered trademark of BioTek Instruments. Vigene Tech is a trademark of Vigene Tech, Inc. Lit. No. PF1089EN00 Rev. Q 10/2012 MIL-118 SBU-12-06179 2012 EMD Millipore Corporation, Billerica, MA, USA. All Rights Reserved.VigeneTech


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