Homogenizer, Homomixer, Nanodisperser, High Pressure Homogenizer, Nono emulsion, nano dispersion, nano liposome, cell rupture, atomization
Impact, shear force, cavitation, High pressure Homogenizer system, impact, shear force, cavitation.
- 1. 2 What is Nano Disperser? PNano Disperser, as a brand of Ilshin Autoclave Co., Ltd, which is commonly called High Pressure Homogenizer, means the technology producing nano-size particle of materials. It is more efficient than other dispersion method such as Homomixer, Ultrasonic waves, Ball mill. When Korea was short of the technology about mixture using high pressure dispersion equipments and various prop- erties of materials, ILSHIN AUTOCLAVE Co.,Ltd managed to develop this dispersion equipments after researching several times. The Nano Disperser what ensures the stability and efficiency is widely used in several areas.
2. 3 ● NANO DISPERSER ● High Pressure Homogenizer System ● NH series ● NL series ● Process Test ● Patents INDEX 3. 4 High Pressure Homogenizer System Pressure Gauge High Pressure Pump Inlet Before After Outlet Heat Exchanger CAVITATIONSHEAR FORCEIMPACT Nozzle Chamber High Pressure Homogenizer System Impact ShearForce Cavitation Surface tension, internal friction force in the orifice and shear force in the fluid by viscosity occurs. When the cavitation bubbles collapse, they force liquid energy to very small volumes, thereby impact between fluid particles occurs. The cavitations means the behavior of voids or bubbles in a liquid. If energy is increased, then cohesive power between molecules and a void or bubble in a liquid rapidly collapses, producing a shock wave. With different operation method unlike conventional disperse, crushers or emulsion equipments, it can produce micro particle with 0.01㎛ size. No intrinsic physical property change because of constant pressure and instant treatment method for production process (Uniform particle distribution, complete homogeneous, productivity improvement). It provides improved treatment speed because of continuous input of materials for production. Its distinguishable performance and durability due to self developed diamond micro orifice module. Easy flux control and cleaning of liquid contact section when replacement of materials. Easy operation for repetition test and pressure readjustment. Easy to scale up and down of flux to have continuous process stabilization. 4. 5 Particle Size Reduction CellDisruption Nano-Encapsulation Pharmaceutical Multi Layer Ceramic Capacitor (MLCC) ● Emulsions ● Suspensions ● Liposomes ● E-coil ● Yeast ● Polymers ● Liposomes ● Emulsions Injectables/ Inhalables/ Parenterals Omega-3/ Plant Sterols/ Vitamins Cell Disruption/ Vaccines Soy Milk/ Food Colorings/ Flavorings Inks/ Ceramics/ Polymers/ Carbon Nanotubes Biotech Chemical Electronics Industry Cosmetic/Nutraceutical Food www.suﬂux.com Ball mill Stir Beads mill Jetmill High Pressure Biology Chemistry Ultrasonic waves Dispersion (d)UltrasonicDisruptorAverage Diameter:66nm (C)UltrasonicBathAverage Diameter:147nm (a)NoPhysicalTreatment AverageDiameter:585nm (b)StirrerAverage Diameter:182nm ParticleNumberFraction(%) Particle Diameter (nm) (e)HighPressureHomogenizer AverageDiamter:45nm Base Fluid: DI-Water Surfactant: SDS (1,0 wt%) 0 100 1000 10 20 30 40 50 60 Applictaiton 5. 6 Series Flow Rate Max. Pressure Nozzle type NH 1000 1L /min 30,000 psi 75 / 100 / 200um NH 2000 2L /min 30,000 psi 75 / 100 / 200um NH 3000 3L/min 30,000 psi 75 / 100 / 200um NH 4000 4L/min 30,000 psi 75 / 100 / 200um * Can be changed upon customer's requirements Specification Size 2,300(D) x 800(W) X 1,500(H)mm Max.flow rate 4L/min ( @ 30,000psi ) Weight 950kg Structure Stainless NH series 6. 7 [PatentNo.10-1073382] [Patent No.10-1085873] [Patent No.10-1073380] [Patent No.10-1036945] NH series 01 02 01 02 Cooling part Material Supply Hydraulic System Chamber Inlet Reservoir Control Unit Nano disperser This is production scale using hydraulic pressure system. It can work continuously for inner cooling system. According to pressure and flow, it can be specially manufactured. Taking account of inner specimen and chemical reaction, multiple materials (PEEK, UHMWPE, PTFE) are used to make sure the durability. Reserviortankandautovalve forpreventingsolidification Add cooler in intensifier to protect seal Disassembling of connect- ing parts is easy Back flashing system for cleaning while chamber is blocked Highpressurehomogenizer preventingsolidificationof materials Highpressurehomogenizer withpumpheadcooler Cleaningstructure&methodof highpressurehomogenizer Simple disassembling of plunger and intensifier 7. 8 Specification Size 310(D) x 450(W) X 300(H)mm Max.flow rate 100ml/min ( @ 22,000psi ) Weight 30kg Structure Stainless NL series * Can be changed upon customer's requirements Series Flow Rate Max. Pressure Nozzle type NLM100 100ml/min 22,000 psi 75um NLM150 150ml/min 22,000 psi 75um NLM200 250ml/min 22,000 psi 75um 8. 9 NL series Inlet Reservoir Pressure Gauge Air Vent Valve Controller www.suﬂux.com To-and-fro motion with screw to pressurize Intensifier air removement is easy [Patent No.10-1103011] Screw type pressure transmitter [Patent No.10-1073381] All-in-one pressure transmitter with air vent This is production scale using hydraulic pressure system. It can work continuously for inner cooling system. According to pressure and flow, it can be specially manufactured. Taking account of inner specimen and chemical reaction, multiple materials (PEEK, UHMWPE, PTFE) are used to make sure the durability. 9. 10 Sample Pressure(Number) Effect Black Lead (Carbon) 2,000kg/㎠ Cell destruction & Atomization CeO2 2,500kg/㎠ Dispersion Raw Materials for cosmetics 1,000kg/㎠ Emulsion Pigment 2,500kg/㎠ Dispersion A high molecular substance 2,500kg/㎠ Cell destruction & Atomization AI2O3 2,000kg/㎠ Dispersion Sample Pressure(Number) Effect Milk 1,800kg/㎠ Dispersion Soybean Milk 2,000kg/㎠ Homogenization CNT 2,000kg/㎠ Dispersion Water+Oil 2,500kg/㎠ Emulsion CERAMIC 2,000kg/㎠ Dispersion TiO3 2,000kg/㎠ Cell destruction & Atomization Z_Average (d.nm) : 1258 Peak 1 : 1094 Size (d.n...) %Intensity Width(d.n...) 98.2 251.7 Peak 2 : 5560 1.8 0.000 Peak 3 : 0.000 0.0 0.000 Pdi : 0.419 Intercept : 0.966 Result quality Refer to quality report Size Distnibution by intensity Intensity(%) 0.1 0 5 10 15 20 25 1 10 100 1000 10000 Z_Average (d.nm) : 254.1 Peak 1 : 300.0 Size (d.n...) %Intensity Width(d.n...) 100.0 111.7 Peak 2 : 0.000 0.0 0.000 Peak 3 : 0.000 0.0 0.000 Pdi : 0.148 Intercept : 0.959 Result quality Good Size Distnibution by intensity Intensity(%) 0.1 0 2 4 6 8 10 12 14 16 1 10 100 1000 Emulsion Ex) Water + Oil / Water Solubility Cream / Silicone Oil Ex) CNT(Carbon Nano Tube)/ Cellulose / Pigment Ex) Carbon black/ Lactose / Titanium Oxide for Cosmetics Rupture Dispersion TEST * Before * After 10. 11 [Patent No.10-1168940] HighPressureDisperserforhighviscositymaterials [Patent No.10-1146618] CoolingSystemforHighPressureDisperseranddisperser’snozzle [Patent No.10-1103011] Screwtypepressuretransmitter [Patent No.10-1085873] Highpressurehomogenizerwithpumpheadcooler [Patent No.10-1073382] Preventingsolidificationofrawmaterial [Patent No.10-1073381] All-in-onepressuretransmitterwithairvent [Patent No.10-1073380] Simpledisassemblingofplungerandintensifier [Patent No.10-1036945] Cleaningstructure&methodofhighpressurehomogenizer 01 05 06 07 08 02 03 04 01 02 03 04 05 06 07 08 Patents Patent www.suﬂux.com 11. ILSHIN AUTOCLAVE Co.,Ltd HeadQuarters (KOREA) 255,Techno 2-ro,Yuseong-gu, Daejeon, Korea (Daedok Techno Valley) Tel: +82-42-931-6100 Fax: +82-42-935-6103 Homepage: www.suflux.com E-mail: firstname.lastname@example.org